Antimicrobial potential of Actinomycetes by NRPS and PKS-I pathways
نویسندگان
چکیده
Background Actinomycetes may account for 10 to 30% of the total soil rhizosphere microorganisms. The attention given to the actinomycetes in biotechnological applications is a result of their metabolic versatility that is accompanied by the production of primary and secondary metabolites of economic importance, which are a promising source of products (e.g., antibiotics, enzyme inhibitors, antiparasitic and anticancer agents) [1,2]. Included in this range of compounds are secondary metabolites synthesized by polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) pathways. An effective method for assessing the presence of these biosynthetic pathways is the detection of PKS and NRPS genes by PCR [3,4]. Thus, this study was based on targeted analyses of 31 soil isolate actinomycetes aiming to evaluate their antimicrobial potential through the NRPS and PKS-I pathways.
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